- use in nuclear medicine
- Contraindications and complications when using
- overdose and interactions
- Additional information
Zoledronic acid - a component of some drugs thatpatented by a Swiss pharmaceutical company.Among the main products that contain this ingredient, you can call Aklasta, blaztera, veroklast, zolendreks and many others.
acid has a selective effect on the bone - or rather, suppresses the activity of osteoclasts, which break down bone man.Therefore, the main indication for the use of - this treatment and prevention of osteoporosis.
second action - anti-cancer, which is especially important in the presence of metastasis of various malignant tumors in the bone.Other indications include:
- Elevated levels Ca blood in the presence of malignant tumors.
- multiple myeloma.
- addition to standard therapy for confirmation of any solid tumor metastases.
use in nuclear medicine
Bone scan is using this drug allows you to achieve
can easily differentiate metastatic lesions of bone-degenerative bone diseases that do not have oncological nature.
At diseases of joints and spine cancer can be specified activity destructive process that occurs in the bones and joints, and it does not carry out any diagnostic surgery.
Contraindications and complications when using
only contraindication - this idiosyncrasy zolendronovoy acid and other drugs that belong to the group of bisphosphonates.To limit the acceptance can be attributed to kidney or liver failure, asthma.
In the application may experience a variety of side effects, so if seen at least one, you must immediately consult your doctor and decide on further treatment.The main and most frequent side effects zolendronovoy acid include:
- bladder infection.
- pain in the bones.
- tumor progression.
during pregnancy is strictly contraindicated, since the acid has a damaging effect on the fetus.Moreover, the treatment is required to protect themselves from pregnancy.
the instructions for use zolendronovoy acid have clear instructions on the dosage.When elevated levels Ca in the blood and the presence of malignant tumors, the appropriateness of admission should be determined by your doctor.The maximum dose at the same time - 4 mg.The substance must be entered into the body via an intravenous infusion, the duration of which shall not be less than 15 minutes.The gap between the first and second administration should be not less than 7 days.
the treatment of myeloma and bone metastases, which appeared in the presence of any solid organ tumors, the dose to be administered is 4 mg, as well as an intravenous infusion, the duration of which shall not be less than 15 minutes.The drug is administered every 3 or 4 weeks to 12 months - so much time is required to complete the course.
overdose and interactions
No cases of overdose for all the practical use of the drug is not registered.
Caution should be observed while the reception with aminoglycosides, which further enhance the reduction of calcium in the blood.Also caution should be appointed, while the reception with a diuretic, which again increases the risk of lowering blood calcium.At simultaneous reception with other drugs that are considered to be nephrotoxic, necessary to revise the dose of the latter.
If you have multiple myeloma and simultaneous reception of thalidomide and zolendronovoy acid several times increases the risk of kidney damage.There is also evidence that products zolendronovoy acid can not dissolve in solutions which contain calcium, for example - in Ringer's solution.
Like any other medicine, zolendronovaya acid has its analogues, the most popular and commonly used can be considered:
- Zolendronat - Teva.
they can apply strictly the appointment after consulting a doctor or an experienced professional - oncologist.
drug has adverse effects on the kidneys, and a single dose should not exceed 4 mg and the duration of infusion should be no less than 15 minutes.Therefore, at the administering for 5 minutes and less risk of renal failure increases several times.But even if the time of administration would be 15 minutes, but the dose is 8 mg, it is also often leads to the fact that the kidneys stop working normally.
Before you start introducing each time is required to determine the level of serum creatinine, and if there will be some changes in the kidneys after the first dose, subsequent treatment is canceled.
During treatment, you need to constantly monitor the level of calcium, phosphorus, magnesium, as well as hemoglobin and hematocrit.When necessary, the adjustment of these substances in the body.