value of insulin deficiency in the origin of specific microangiopathy advisable to check the secondary, symptomatic diabetes in patients with chronic pancreatitis, pancreatic cancer, hemochromatosis.Under these conditions with an absolute insulin deficiency in patients usually do not have a genetic predisposition to diabetes.Analysis of the literature shows that the secondary diabetic microangiopathy are described only in isolated cases, but these cases are of fundamental importance.Hudson (1953), diabetic retinopathy found in 2 patients with diabetes, hemochromatosis.Burton et al. (1957) observed diabetic retinopathy in a diabetic patient after pancreatectomy.Becker and Miller (1960), 7 out of 22 diabetic patients motivated hemochromatosis showed signs of diabetic glomerulosclerosis, from 30 patients with hemochromatosis without disturbance of carbohydrate metabolism in any case was not glomerulosclerosis.The authors contrasted their data to the research Lonergan and Robbins (1959), which none of the 6

2 patients with diabetes on the basis of secondary hemochromatosis did not find a typical glomerulosclerosis.A combination of specific nephropathy and retinopathy in a patient with chronic pancreatitis, diabetes secondary reported Duncan et al. (1958), and Shapiro et al. (1966).MacDonald and Ireland (1964) in patients suffering from several years of chronic pancreatitis with impaired carbohydrate tolerance, found in the section along with fibrotic changes in the pancreas of diabetic glomerulosclerosis signs.These authors also reported thickening of the basement membrane of the glomerular capillaries in three posthumously investigated cases of chronic pancreatitis and hemochromatosis with impaired glucose metabolism.All these cases demonstrate the importance of insulin deficiency (at least as one of the leading factors) in the development of microangiopathy in patients with diabetes.

Tags: hemochromatosis, pancreatitis