anemia Addison Biermer value immunopathological mechanisms in the implementation of genetically caused anemia Addisona- Biermer shown in recent years, many studies (for a review of our work is given in -A. J. Geller).Ungar et al., Patients with diabetes have noted the presence of antibodies against biermerin in 4% with 1% in the control group.In patients with juvenile diabetes legitimate family history autoantibodies against intrinsic factor is more common than in diabetics without clear indications of genetic determinism, which further supports the concept of the community of two genetically caused pathological processes with autoimmune mechanisms.On the "clinical crossroads" of diabetes and anemia Addison-Biermer show materials research Aparakis and others.

Clinical observations of patients with diabetes treated with sulfa drugs, have shown the possibility of development in individual cases agranulocytosis, sometimes thrombocytopenia and anemia (Aarseth, Willumsen; Chapman,Cheung; Traissac ea).It must be emphasized that,

as a rule, in cases of agranulocytosis or destruction of all three germ hematopoiesis were observed in patients with both lesions on the skin and mucous membranes, which gave reason to believe the cause of all violations of toxic and allergic reactions to sulfa antidiabetics.Here is an excerpt from the history we observe the patient who is having this type of reaction.

information about the frequency of less severe changes in hemogram sulfanilamidnymi drugs among treated patients with diabetes are not uniform.LA Golubeva revealed a significant decrease in the number of white blood cells during therapy sulfanilamidnymi drugs in 10 of 25 examined patients with diabetes, low platelet counts - 8 out of 15 patients.The observations O. Sh Bostanjian leukopenia occurred in 8% of patients treated with drugs sulfanilamidnymi diabetes.In a series of studies LV Laptenok leukopenia occurred in 8 of the 134 treated with sulfa drugs anti-diabetic individuals, and thrombocytopenia - 6 out of 32 surveyed.