Overweight people have a greater risk type II diabetes , diseases, when the body can not control glucose.Communication diabetes and obesity is statistically obvious biological reasons not so clear.Now, scientists from the Institute of Molecular and Cell Biology in Singapore have found that obese people are missing a key protein that controls glucose.
Obesity is a common serious disease that increases the risk of stroke, heart disease, type II diabetes and some types of cancer, which are the leading causes of preventable death.According to statistics from obesity are now suffering more than a third of US adults, which in 2008 cost the country $ 147 billion.
Previously, obesity was considered a problem only in rich countries, but now obesity is increasing rapidly in countries with low and middle-income countries, mainlyin cities.Type II diabetes occurs when the body does not produce the right amount of insulin, which helps him to control glucose, or the body's cells develop resistance to insulin.As a
more than 360 million. People in the world suffer from diabetes of type II.The World Health Organization gives the prognosis that diabetes is the 7th cause of death worldwide in 2030.
NUCKS protein regulates insulin secretion in cells
According to the site kliniki.ru, in his study, doctors found that a protein NUCKS - an important regulator of insulin signaling in cells.Endocrine cells are deprived of the ability to produce the protein damage insulin signaling.Furthermore
grown with mouse showed absence NUCKS "reducing insulin signaling and increase in body weight / body fat mass, along with impaired glucose tolerance and decreased insulin sensitivity that was compounded in addition high fat" physicians mark.
NUCKS suppressed, i.e. genes that encode a protein, more or less passive just in obese individuals.The same happens with the genes in mice fed a high-fat diet, with levels up to NUCKS starvation.
researchers suggest that obese people who lack NUCKS, develop insulin resistance and lose the ability to properly regulate blood sugar, which leads to its high content in the blood and diabetes.
Scientists say it is the first time that has found a direct molecular link obesity and diabetes type II, which will lead to new research and development projects to create medicines and lifestyle changes that can restore NUCKS proteins in the body to normal levels.